This town is not on the Nicoya Peninsula, but rather on Costa Rica's mainland. It is best known as a cruise-ship port and launching pad for ferries heading southeast to the coast of the Nicoya Peninsula and for cruises sailing out on the Gulf of Nicoya. Puntarenas is also a major fishing port with a lively fish market. The town’s reputation suffers from the unimpressive parts you see from your car as you roll through town on the way to the ferry dock. But the town has a lot of character off the main drag, thanks to its illustrious past as an affluent port town and principal vacation spot for San José's wealthy, who arrived by train in the last century. Once the port was moved and roads opened to other beaches, Puntarenas's economy crashed, but it's making a comeback. Sitting on a narrow spit of sand—punta de arenas literally means "point of sand"—that protrudes into the Gulf of Nicoya, the town boasts a beautifully groomed, wide Blue Flag beach with views of the Nicoya Peninsula and spectacular sunsets, along with a public swimming pool, the San Lucas Beach Club, and a marine-life museum. Ticos arrive by bus and car to enjoy the beach and stroll the Paseo de los Turistas, a beachfront promenade lined with tree-shaded concrete benches and seafood restaurants. Crowds of locals, called porteños, cruise by on bicycles, the town’s most popular form of transport.

Golfito, is situated along a small inlet of Golfo Dulce. This small port city is a narrow strip along Golfito Bay backed against steep green hills covered with pristine rainforest, with the Golfo Dulce seaward outside Golfito Bay. Surrounded by tropical rainforest, Golfito provides an ideal location to escape from your hectic schedule and enjoy some of the most beautiful beaches in Costa Rica with a stunning backdrop of verdant hills and lush rainforest. Follow a trail through the densely forested Golfito National Wildlife Refuge to observe rare flora and fauna, and emerge at a scenic outlook with views of the ocean, also the city has a variety of hotels and restaurants, many of which now provide free wireless Internet service for customers. Golfito was the main port on the South Pacific Coast of Costa Rica in the days when there was little except for the huge banana plantations. To help remedy the resulting economy decrease of the region, the government established a duty-free zone, support and impulse the touristic development.

"The remote Darien Jungle has one of the most biodiverse ecosystems in the world. It is also one of the world’s top ten birding sites, with the colourful Crimson-collared Tanager, Chestnut-fronted Macaws, and Snow-bellied Hummingbirds found here. Mammals include tapirs and Black-headed Spider Monkeys. In this roadless stretch of forest, rivers provide the best access. Visitors to the Darien Jungle are rare with fewer than 1,000 tourists visiting each year. The Embera are one of several indigenous groups that live here in relative isolation offering ornate handcrafted baskets and carvings for sale in their traditional villages."

The San Blas archipelago is located off the Caribbean coast, east of Colon, and is made up of 365 islands that range in size from tiny ones with a few coconut palms to islands on which hundreds of Kuna Indians live. Only about fifty are inhabited. The Kuna rule the San Blas Territory with internal autonomy, and have tightly preserved their language and cultural traditions over the centuries despite influences from European colonies. In addition to their own language, Spanish is widely spoken and many men work on the mainland, but live on the islands. Women wear costumes with unique designs based on local themes, geometric patterns, and stylised fauna and flora. The island of El Porvenir is one of the main seats of government for the Kuna Indians. Many Kunas from the other islands came to settle on El Porvenir, bringing with them their traditional arts and crafts, including the famous molas. These intricately hand-sewn designs are made by the women of the tribes as part of their blouses and dresses. With the increased tourism, molas are now a favoured souvenir and craft item for visitors.

The provincial capital of Colón, beside the canal's Atlantic entrance, is named for the Spanish-language surname of Christopher Columbus, though the Americans called it Aspinwall in the 19th century.. The city was founded in 1850 by Americans working on the Panama railroad and named Aspinwall for one of the railway engineers. Following completion in 1855, Colon gained in importance, which was furthered by the plans for an isthmian canal. During the time of the French canal attempt, a fire in 1885 burned the city nearly to the ground and left thousands of people homeless. Colon was rebuilt in the architectural style then popular in France. Buildings from that era plus the ones constructed by Americans between 1904 and 1914 are still in use today, although the majority is on the verge of collapse. In addition to its importance as a port, Colon boasts the world’s second largest duty-free zone, known as Zona Libre, which is contained in a huge fortress like, walled-off area with giant international stores. However, most of the merchandise is sold in bulk to commercial businesses throughout the country.